Keynote Speaker


Doheon Lee (KAIST, BSRC, Korea)
Recently, there are growing interests in combinational bio-agents interacting with multiple targets to overcome the limitations of the current single target approaches. Many drug development efforts based on the Paul Ehrlich's magic bullet principle, where a single therapeutic agent with ideal selectively could successfully regulate a single target causing a particular disease, have been suffering critical hindrances including unwanted off-target effects and degraded efficacy. Synergistic regulation of multiple targets with multiple agents is expected to remedy those hindrances. Furthermore, recent trends of preventive and participatory healthcare require more comprehensive spectrum of bio-agents for disease prevention as well as treatment. This talk introduces a Korean national initiative where multiple-agent-multiple-target systems biology technology for natural product-based healthcare is being developed. Central components of the technology platform are virtual cell and human systems, which are computational models of molecular, cellular, and organ-level physiological mechanisms. The synergistic effects of multiple agents on multiple targets are simulated and predicted with those virtual systems, and validated in real systems including model cells and animals.

Title: Systems Informatics Initiative for Natural Product-Based Healthcare Technology

Abstract:
Recently, there are growing interests in combinational bio-agents interacting with multiple targets to overcome the limitations of the current single target approaches. Many drug development efforts based on the Paul Ehrlich¡¯s magic bullet principle, where a single therapeutic agent with ideal selectively could successfully regulate a single target causing a particular disease, have been suffering critical hindrances including unwanted off-target effects and degraded efficacy. Synergistic regulation of multiple targets with multiple agents is expected to remedy those hindrances. Furthermore, recent trends of preventive and participatory healthcare require more comprehensive spectrum of bio-agents for disease prevention as well as treatment. This talk introduces a Korean national initiative where multiple-agent-multiple-target systems biology technology for natural product-based healthcare is being developed. Central components of the technology platform are virtual cell and human systems, which are computational models of molecular, cellular, and organ-level physiological mechanisms. The synergistic effects of multiple agents on multiple targets are simulated and predicted with those virtual systems, and validated in real systems including model cells and animals.